2019 sem 3

 immunology

 Q1) Attempt any two of the following : [10] a) Explain the structure of B-cell receptor. b) Describe the role of adhesion molecules in immune activation. c) Describe JAK / STAT signal transduction pathway. Q2) Attempt any two of the following : [10] a) Explain the mechanisms of tolerance induction by giving experimental evidences. b) Diagrammatically explain regulation of classical complement pathway. c) Explain the role of Antigen in regulation of immune response. Q3) Attempt any two of the following : [10] a) What are primary cell cultures and cell lines? b) Describe ELISPOT assay and give its application. c) Describe the use of animal models in studying AIDS. P.T.O. 2 [5534]-301 Q4) Attempt any two of the following : [10] a) Describe the role of Toll like receptors in innate immunity. b) Describe Idiotypic network theory and its experimental evidence. c) Describe functional assays for phagocytes. Q5) Attempt any two of the following : [10] a) Describe escape mechanisms of tumors from host defense. b) Differentiate between tumor specific antigens and tumor associated antigens. c) Describe tumor vaccine therapy with examples. Q6) Attempt any two of the following : [10] a) Describe the pathophysiology in Salmonella infections. b) How does the host immune system respond to HIV infections. c) Describe the immunotherapeutic approaches to bacterial infections. Q7) Attempt any two of the following : [10] a) What are complement deficiencies and how are they diagnosed? b) Explain the mechanisms of symptoms development in Myasthenia gravis. c) Describe immunotherapeutic approaches to systemic Lupus Erythomatosus (SLE). Q8) Attempt any two of the following : [10] a) Describe the evolution of cellular immune defenses in invertebrates. b) Explain the complexity of immune cells in different species of vertebrates. c) Describe the diversity of humoral immunity components in different species of vertebrates.

 molecular biology